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Literature summary extracted from
- Inhibition of the ATPase activity of the catalytic portion of ATP synthases by cationic amphiphiles (2008), Biochim. Biophys. Acta, 1777, 362-368.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.14 | cetyltrimethylammonium bromide | i.e. CTAB, Mg2+-ATPase activity of ECF1 is very resistant to inhibition by cetyltrimethylammonium bromide, lower concentrations of cetyltrimethylammonium bromide stimulate Mg2+-ATPase activity of ECF1 | Escherichia coli |  |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.2.2.14 | additional information | Mg2+-ATPase activities of CF1 deficient in its inhibitory epsilon subunit, CF1-epsilon, are sensitive to inhibition by melittin and by cetyltrimethylammonium bromide. Sulfite-activated Mg2+-ATPase activity of CF1-epsilon is inhibited by cetyltrimethylammonium bromide | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.14 | cetyltrimethylammonium bromide | Mg2+-ATPase activity of ECF1 is very resistant to inhibition by cationic detergents melittin and cetyltrimethylammonium bromide, lower concentrations of cetyltrimethylammonium bromide stimulate Mg2+-ATPase activity of ECF1. MgATP protects, overview | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.14 | ATP + H2O + Mg2+/out | Escherichia coli | - |
ADP + phosphate + Mg2+/in | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.14 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.14 | ATP + H2O + Mg2+/out | - |
Escherichia coli | ADP + phosphate + Mg2+/in | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.14 | ECF1 | - |
Escherichia coli |
| 7.2.2.14 | Mg2+-ATPase | - |
Escherichia coli |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.14 | 37 | - |
assay at | Escherichia coli |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.14 | 8 | - |
assay at | Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.14 | ATP | - |
Escherichia coli | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 7.2.2.14 | 0.01 | 0.015 | pH 8.0, 37°C, inhibitory epsilon subunit, CF1-epsilon | Escherichia coli | cetyltrimethylammonium bromide | |
| 7.2.2.14 | 0.025 | - |
pH 8.0, 37°C, ECF1 | Escherichia coli | cetyltrimethylammonium bromide | |
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Release 2023.1 (January 2023)
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